There’s a reason that recreational users of psychedelic mushrooms have long referred to the fungi as “magic.” And it turns out, it could be for more than just the euphoric high.
According to a study published in Scientific Reports conducted by Imperial College London, researchers found evidence that suggests psilocybin, the psychoactive compound of magic mushrooms, might also be useful in treating depression.
For the study, researchers focused on 19 patients, all of which experienced treatment-resistant depression. Each patient showed fewer depressive symptoms at the one-week post-treatment mark.
It is important to note that while the findings are exciting, this study is very preliminary as it was based on a small number of people and with no control sample.
“We have shown for the first time clear changes in brain activity in depressed people treated with psilocybin after failing to respond to conventional treatments,” lead author Dr. Robin Carhart-Harris, head of psychedelic research at Imperial, said in a statement.
Each patient in the study was given two doses of psilocybin – the first dose at 10 mg was administered immediately, the second dose of 25 mg was given one week later.
Results showed that patients reported feeling recharged after the experience.
“Several of our patients described feeling ‘reset’ after the treatment and often used computer analogies,” Dr. Carhart-Harris reported. “For example, one said he felt like his brain had been ‘defragged’ like a computer hard drive, and another said he felt ‘rebooted’.
“Psilocybin may be giving these individuals the temporary ‘kick start’ they need to break out of their depressive states and these imaging results do tentatively support a ‘reset’ analogy. Similar brain effects to these have been seen with electroconvulsive therapy.”
As part of the study, researchers performed functional magnetic resonance imaging (fMRI) on 16 of the 19 patients both before and after treatment. The scans indicate a reduction in cerebral blood flow towards the temporal cortex, in particular, the amygdala. This decrease in blood flow to the amygdala was related to a decrease in depressive symptoms. The MRI also showed increased stability in another brain network linked with depression.
“Through collecting these imaging data we have been able to provide a window into the after-effects of psilocybin treatment in the brains of patients with chronic depression,” Dr. Carhart-Harris added.
“Based on what we know from various brain imaging studies with psychedelics, as well as taking heed of what people say about their experiences, it may be that psychedelics do indeed ‘reset’ the brain networks associated with depression, effectively enabling them to be lifted from the depressed state.”
The team is very encouraged by their results and plan to run a comparative trial in the next year to test the effectiveness of psilocybin against leading antidepressants.
It appears there may be more magic in mushrooms than what we previously understood. We’d love to hear your thoughts on the findings and if you found this article interesting, please share with friends and family by clicking the button below.